Farzaneh Tondnevis

I was born and raised in Tehran, Iran. I moved to the states in 2004 and attended De Anza college in Cupertino CA for three years. I transferred to University of California Santa Cruz and received my bachelor degree in Biochemistry and Molecular Biology in 2009. I did undergraduate research in laboratory of Dr. Harry Noller studying the conformational changed of EF-G (Elongation Factor G) using FRET during translation. I joined IDP at UF in Fall of 2010 and have been working on E. coli gamma complex (clamp loader) as well as working on a bacteriophage N4 encoded protein gp8 which has been reported to abolishes host DNA replication as part of itís life cycle. I am hoping to identify a novel antibiotic target (aka the clamp loader) while studying the mechanism of inhibition of E. coli replication by this small polypeptide. I use a wide range of biophysical and biochemical techniques such as X-ray crystallography, SAXS, CD and ITC and a variation of fluorescence assays in my studies. I have also several other projects working on T. cru alpha CA, p37 thiamine binding protein from Mycoplasma hyorhinis, and looking at different mutants of clamp loader.

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