Ongoing Research Support

NIH/NHLBI

P01 HL51811 Guggino (PI)
05/01/04 - 04/30/09
Title: Gene and Pharmacological Therapies for Cystic Fibrosis - Biology of Adeno-Associated Viral Vectors (Project 4).
The Lab's role on this project is structure-function studies of the AAV4 and AAV5 capsids. Information obtained from this project could aid the proposed use of three-dimensional structure information for analyzing subunit interfaces.
Role: Co-investigators Mavis Agbandje-McKenna and Robert McKenna

NIH/NHLBI

P01 HL51811 Muzyczka (PI)
09/01/02 - 08/31/07
Title: Studies of AAV Capsid Assembly, Viral Entry, and Viral Tropism (Project 1).
The Lab's role on this project are to determine the structure of the AAV2 capsid in complex with heparin sulfate and a monoclonal antibody or antibody fragments in an effort to elucidate regions on the capsid that are required for receptor attachment and capsid assembly.
Role: Co-investigator Mavis Agbandje-McKenna

NIH/DK

P01 DK58327 Flotte (PI)
07/01/05 - 06/30/08
Title: Recombinant AAV for Correction of Genetic Abnormalities.
The Lab's role on this project is the expression, purification, crystallization, and structure determination of human a-glucosidase.
Role: Co-investigator Robert McKenna

NIH/DK

R01 DK52356 Bungert (PI)
08/01/02 - 07/31/06
Title: Structure and Function of the Human -globin LCR.
The Lab's role on this project is the analysis of the Human -globin LCR by electron microscopy.
Role: Co-investigator Mavis Agbandje-McKenna

NIH/GM

RO1 GM25154 Silverman (PI)
05/01/04 - 04/30/08
Title: Catalytic Mechanism of Carbonic Anhydrase.
The Lab's role on this project is to expand the use of the carbonic anhydrases to understand the rate-limiting proton transfer steps in a way that can be extended to other proteins.
Role: Co-investigator Robert McKenna

NSF

MCB-0212846 Agbandje-McKenna (PI)
07/01/02 - 06/30/06 (no cost extension)
Title: Structural Analysis of Virulence Determinants and Genomic DNA packaging Constraints in a ssDNA Virus.
The Lab's role on this project is to elucidate the structural determinants of viral host cell tissue tropism and pathogenicity and identity a possible genomic recognition motif for the ssDNA parvoviruses.
Role: PI

NSF - Nanoscale Exploratory Research

NER 00051444 Sitharam (PI)
07/01/04 - 06/30/06(no cost extension)
Title: NER: Geometry and Tensegrity based computational modeling of virus assembly pathways.
The Lab's role on this project is to correlate the development of computational and mathematical models of virus assembly to be validated by wet lab experiments.
Role: Co-investigator Mavis Agbandje-McKenna

NSF - EIA - Revolutionary Computing

EIA-0218435 Sitharam(PI)
09/01/02 - 08/31/06 (no cost extension)
Title: Virus-Inspired Declarative Geometric Computation.
The Lab's role on this project is to at isolating the components of viral capsid assembly, using the unique geminivirus capsid as a model, utilizing the combined disciplines of computational biology and biochemistry.
Role: Co-investigator Mavis Agbandje-McKenna

Thomas H. Maren Foundation

McKenna (PI)
02/01/06 - 01/31/08
Title:Structural and Kinetic Studies of a-class Carbonic Anhydrases
The Lab's role on this project is to study structurally various isoforms of carbonic anhydrases.
Role: PI

American Cancer Society

Shiverick (PI)
01/01/06 -12/31/06
Title: UF Experimental Therapeutics/Carbonic Anhydrase IX Drug Design Working Group.
The Labs role on this project is to determine the three-dimensional structure of CA IX using X-ray crystallographic methods.
Role: Co-investigator Robert McKenna

Completed Research Support (Last THREE years)

Thomas H. Maren Foundation

McKenna(PI)
06/20/02 - 06/19/05
Title: Proton Mapping the Active Site of Human Carbonic Anhydrase II.
The Lab's role on this project was to initiate ultra-high resolution X-ray and neutron diffraction studies of wild type human carbonic anhydrase II.
Role: PI

American Cancer Society

McKenna (PI)
01/01/04 - 12/31/04
Title: Structural Studies of the tumor metastasis factor p37.
The Lab's role on this project was to determine the three-dimensional structure of p37 using X-ray crystallographic methods.
Role: PI


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