Lab published research papers (sorted by year). Click on the publication link to access a PDF version


Yang L., J. Jiang, L. M. Drouin, M. Agbandje-McKenna, C. Chen, C. Qiao, D. Pu, X. Hu, D. Z. Wang, J. Li, X. Xiao. 2009. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proc Natl Acad Sci U S A., 106:3946-51.
Yang 2009

Mays L. E., L. H. Vandenberghe, R. Xiao, P. Bell, H.-J. Nam, M. Agbandje-McKenna, J. M. Wilson JM. 2009. Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. J Immunol. 182:6051-60.
Mays 2009

Van Vliet K, Y. Mohiuddin, S. McClung, V. Blouin, F. Rolling, P. Moullier, M. Agbandje-McKenna R.O Snyder. 2009. Adeno-associated virus capsid serotype identification: Analytical methods development and application. J Virol Methods. 159:167-77.[Epub ahead of print 2009 Mar 26]
Van Vilet 2009

Li W., L. Zhang, J. S. Johnson, W. Zhijian, J. C. Grieger, X. Ping-Jie, L. M. Drouin, M. Agbandje-McKenna M, R. J. Pickles, R. J. Samulski. 2009. Generation of Novel AAV Variants by Directed Evolution for Improved CFTR Delivery to Human Ciliated Airway Epithelium. Mol Ther. 17:2067-77. [Epub ahead of print].
Li 2009

Vandenberghe, L.H., Breous, E., Nam, H.-J., Gao, G., Xiao, R., Sandhu, A., Johnston, J., Debyser, Z., Agbandje-McKenna, M., Wilson J.M. 2009. Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Ther. 16:1416-1428. [Epub ahead of print 2009 Dec].
Vandenberghe 2009

Asokan A., Conway, J. C., Phillips J. L., Li C., Hegge J., Sinnott R., Yadav S., DiPrimio N., Nam H.-J., Agbandje-McKenna M., McPhee S., Wolff J., Samulski R. J. 2010. Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle. Nat Biotechnol. 28:79-82. Epub 2009 Dec 27.
Asokan 2009

Levy, H. C., V. D. Bowman, L. Govindasamy, R. McKenna, K. Nash, K. Warrington, W-J. Chen, N. Muzyczka, X. Yan, T.S. Baker, M. Agbandje-McKenna. 2009. Heparin binding induces conformational changes in Adeno-associated virus serotype 2. J. Struct. Biol. 165: 146-56.
Levy 2009

Fisher, S. Z. , A. Y. Kovalevsky, J. F. Domsic, M. Mustyakimov, D. N. Silverman, R. McKenna, P. Langan. 2009. Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II. Acta Crystallogr., F65: 495 – 498.
Fisher 2009

Genis, C., K. H Sippel, N. Case, W. Cao, B. S. Avvaru, L. J. Tartaglia, L. Govindasamy, C. K. Tu, M. Agbandje-McKenna, D. N. Silverman, C. J. Rosser, R. McKenna. 2009. Design of a carbonic anhydrase IX active-site mimic, to screen inhibitors for possible anti-cancer properties. Biochemistry 48: 1322-1331.
Genis 2009

Robbins, A. H., B. M. Dunn, M. Agbandje-McKenna, R. McKenna. 2009. Crystallographic evidence for non-coplanar catalytic aspartic acids in an aspartic protease resides in the Protein Data Bank. Acta Crystallogr., D65:294-296.
Robins 2009

Liu P., M. R. Marzahn, A. H. Robbins, H. Gutie´rrez-de-Tera´n, D. Rodri´guez, S. H. McClung, S. M. Stevens, C. A. Yowell, J. B. Dame, R. McKenna, B. M. Dunn. 2009. Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum: Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis. Biochemistry, 48: 4086-4099.
Liu 2009

Sippel, K. H., A. H. Robbins, R. Reutzel, S. K. Boehlein, K. Namiki, S. Goodison, M. Agbandje-McKenna, C. J. Rosser, R. McKenna. 2009. Structural insights of the Mycoplasma hyorhinis protein Mh-p37: A putative thiamine pyrophosphate transporter. J. Bacteriology, 191: 2585-2592.
Sippel 2009

Maupin, C.M., R. McKenna, D.N. Silverman, G.A. Voth. 2009. Elucidation of the proton transport mechanism in human carbonic anhydrase II. J. Am. Chem. Soc., 131: 7598-7608.
Maupin 2009

Mitchell, M., H.-J. Nam, A. Carter, A.McCall, C. Rence, A. Bennett, B. Gurda, R. McKenna, M. Porter, Y. Sakai, B. J. Byrne, N. Muzyczka, G. Aslanidi, S. Zolotukhin, M. Agbandje-McKenna. 2009. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta Crystallogr., F65: 715–718.
Mitchell 2009

Avvaru, B. S., S. A. Busby, M. J. Chalmers, B. Venkatakrishnan, M. Agbandje-McKenna, P. R. Griffin, D. N. Silverman, R. McKenna. 2009. Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry. 48:7365-7372.
Avvaru 2009

Maupin C. M., J. Zheng, C. K. Tu, R. McKenna, G. A. Voth, D. N. Silverman. 2009. Effect of active-site mutations on the proton transfer mechanism of human carbonic anhydrase II. Biochemistry 48:7996-8005.
Maupin 2009a

Sippel, K.H, S. K. Boehlein, Y. Sakai, J. G. Quirit, M. Agbandje-McKenna, C. J. Rosser, R. McKenna. 2009. Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289. Acta Crystallogr., F65:910-912.
Sippel 2009a

Sippel, K. H., A. H. Robbins, J. Domsic, C. Genis, M. Agbandje-McKenna, R. McKenna. 2009. High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design. Acta Crystallogr., F65:992-995.
Sippel 2009b

Avvaru, B. S., C. U. Kim, K. H. Sippel, S. M. Gruner, M. Agbandje-McKenna, D. N. Silverman, R. McKenna. 2009. A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry. 49:249-251.
Avvaru 2009a

Other Years


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