Structural Insight into the Catalytic Mechanism of Carbonic Anhydrase.
We are interested in using various structural techniques (from X-ray crystallography, neutron diffraction, to molecular modeling) to study the detailed structure of wild-type, mutant, and inhibited and chemically rescued complexes of CAs .

Project description

 
Understanding the Structural Topology of Adeno-Associated Viruses.
We are interested in studying structure/function relationships of the AAV capsid - to understand virus assembly, host cell receptor recognition, antibody interactions etc. This information will be used to aid the application of AAVs in gene delivery.

Project description

 
Structural Study on the Quaternary Organization of human Mn SuperOxide Dismutase.
We are interested in correlating kinetic and structural effects of mutations on the interfacial(dimer and tetramer) contacts of human MnSOD.

Project description

 
Structural Insight into the Pathogenicity of Minute Virus of Mice.
We are interested in how the MVM capsid structure plays a role in controlling the tropism and pathogenicity of this family of viruses.

Project description

 
Structural Study of the Assembly Pathway of Maize Streak Virus.
We are interested in elucidating the steps involved in the capsid assmbly of this unique family of twinned quasi-isometric (geminate) T=1 icosahedral virions, that are assembled from 110 copies of their capsid protein.

Project description

 


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